CBN may alleviate Alzheimers Disease

Groundbreaking research has found that cannabinol (CBN), one of the less famous compounds of cannabis, may potentially aid in preventing and treating age-related neurodegenerative diseases, such as Alzheimer’s.

Scientists have a comprehensive understanding of the properties and effects of THC and CBD, two cannabis compounds that have become well known in recent years and analysed in research for decades. However, less is known about the therapeutic properties of cannabinol.

Now, a team of researchers from Salk have conducted a revolutionary study, discovering that CBN protects nerve cells from oxidative damage, a significant driver of cell death. The findings may help to devise novel strategies that employ cannabinol to mitigate a range of neurodegenerative diseases.

Pamela Maher, the senior author of the research and a research professor and head of Salk’s Cellular Neurobiology Laboratory, said: “We’ve found that cannabinol protects neurons from oxidative stress and cell death, two of the major contributors to Alzheimer’s. This discovery could one day lead to the development of new therapeutics for treating this disease and other neurodegenerative disorders, like Parkinson’s disease.”

The study was funded by the National Institutes of Health, the Paul F. Glenn Center for Biology of Aging Research at the Salk Institute, an Innovation Award from the Salk Institute, the Shiley Foundation, the Bundy Foundation, and the University of California San Diego.

What is cannabinol?

Cannabinol is derived from the cannabis plant, and although it is molecularly similar to THC, it does not share the same psychoactive properties and is subsequently less heavily regulated by the FDA. Previous research performed by Maher’s team identified that cannabinol has neuroprotective qualities, with this new research illuminating the mechanism in CBN that protects brain cells from damage and death.

Uncovering neuroprotective properties

The team investigated the process of oxytosis – otherwise known as ferroptosis – which is believed to occur in an ageing brain and may cause Alzheimer’s disease. Oxytosis can be triggered due to the gradual loss of the antioxidant glutathione, resulting in neural cell damage and death through lipid oxidation. The researchers administered cannabinol to nerve cells in their study and then introduced an agent to stimulate oxidative damage.

The results demonstrated that CBN works by protecting the mitochondria that power the cells within the neurons; oxidation causes mitochondria to curl up like doughnuts in damaged cells, a change displayed in the ageing cells of people with Alzheimer’s disease. The CBN treatment prevented this from happening to the mitochondria and enabled them to continue to function correctly. To reinforce their findings, the team replicated the experiment in nerve cells with no mitochondria; here, CBN no longer displayed its protective effect.

Additionally, the team identified that cannabinol did not activate cannabis receptors, which causes cannabinoids to produce a psychoactive response, meaning it could be administered without causing an individual to become “high”.

Zhibin Liang, the first author of the research and a postdoctoral fellow in the Maher lab, commented: “CBN is not a controlled substance like THC, the psychotropic compound in cannabis, and evidence has shown that CBN is safe in animals and humans. And because CBN works independently of cannabinoid receptors, CBN could also work in a wide variety of cells with ample therapeutic potential.”

“Mitochondrial dysfunction is implicated in changes in various tissues, not just in the brain and ageing, so the fact that this compound is able to maintain mitochondrial function suggests it could have more benefits beyond the context of Alzheimer’s disease,” Maher said.

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CBD neuroprotective properties: concentration and memory

CBD – cannabidiol, a bioactive part of the Cannabis plant is becoming popular due to its potential benefits for the mind and body.

It would seem that CBD is useful for concentration and memory due to its neuroprotective properties. Some studies confirm a very interesting fact, that CBD plays an important role in mitigating the memory impairment induced by THC.

Implicitly, then, it is suggested that cannabidiol may have concrete properties to support the ability to retain memories.Concentration and Memory Lack of concentration can have troublesome impacts on humans, including loss of time and poor execution of one’s work.

Individuals affected by this condition, may run into endless fatigue that can only exacerbate the situation. As well as concentration, memory plays a vital role in everyday life. Whether in the work field or not, it represents an advantage that can come in handy in times of need.

It usually lasts about 60 seconds. Long-term memory is the ability to store and remember information for longer periods of time, indefinitely. Long-term memory can be further broken down into different categories, including explicit memory, implicit memory, and autobiographical memory.

Unfortunately, there are several diseases that take over this capacity. Preventing us from being able to relive our fondest memories, or even worse not being able to be autonomous. There is a small but growing amount of scientific evidence showing that CBD can help the brain and improve memory.

CBD has been found to promote neurogenesis and as a result reduce damage to cognitive function caused by age, disease, and trauma.

How does CBD work?

CBD interacts directly with dopamine in the brain, which is a chemical neurotransmitter responsible for memory, concentration and mental awareness. At the point when an individual possesses lower attention and concentration, this implies that dopamine levels are low.

Ingesting CBD does not allow for an irregular increase in dopamine levels in the brain. Instead, the correct composition of CBD oil from the right variety will help improve concentration and overall performance at school and at work.

Keeping the brain healthy as we age is crucial. In an aging brain, age-related cognitive decline is due to many factors ranging from genetics to lifestyle habits, it is also partly due to a decrease in neuroplasticity and neurogenesis.

Neuroplasticity is the brain’s ability to change and reorganize and is the process through which the processes of all memory and learning occur.

CBD also acts on trauma, i.e. unpleasant memories. Clinical studies carried out on people who have suffered post-traumatic stress, show how important is the mitigating and relaxing action of CBD in the removal of unpleasant memories.

Neurogenesis is the birth of new brain cells. Cbd with its neuroprotective properties assists the natural aging process, minimizing damage.

The first effects are stress reduction and a lowering of anxiety and fear.

Neuroprotective properties

There is a study, published in 2010 in The British Journal of Psychiatry, in which the effects of CBD and THC on acute memory were compared.

This study revealed that THC (tetrahydrocannabinol) and CBD (cannabidiol), have different effects on a person’s brain.

In the brain, THC and CBD act on some of the same receptors – CB1 and CB2 – these receptors affect appetite, pain, memory, and mood.

Scientists believe that CBD’s neuroprotective effect is due to its action on CB2 receptors. It acts on this particular receptor to generate anti-inflammatory responses in brain cells, therefore, minimizing the damage that could be caused by inflammation.

A study published in Frontiers in Pharmacology, for example, shows how CBD promotes neurogenesis (neuronal growth and regrowth): basically it reduces and prevents the deterioration of cognitive function.

The analysis deals with the properties and possible developments of CBD as a neuroprotector in relation to brain damage.

We can state that CBD, often demonized because it is associated with cannabis, should not be seen as a drug that impairs memory.

On the contrary, being composed of many active ingredients and cannabinoids, it turns out to be a carrier of favorable effects on our body.

The analysis deals with the properties and possible developments of CBD as a neuroprotector in relation to brain damage.

They will also be able to assist in the reduction over time, of cognitive disorders related to some neurodegenerative diseases.